Национальный МЭГ-Центр МГППУ совместно с НИУ ВШЭ организует семинар

МЭГ-Центр МГППУ

Национальный МЭГ-Центр МГППУ совместно с НИУ ВШЭ организует семинар «Хирургическое лечение эпилепсии на основе использования новых биомаркеров и оценки определенных когнитивных функций мозга»

Tommaso Fedele - Assistant professor, Institute of Cognitive Neuroscience Higher School of Economics - National Research University

Язык семинара - английский

- Date: 05.02.2019

- Time: 17:00

- Address: Shelepikhinskaya Naberezhnaya, 2А, ‘G’ 3rd floor, room 304 http://megmoscow.com/ 

Summary

Nowadays, about one third of epilepsy patients are refractory to pharmacological treatment, becoming candidate for surgical intervention. Surgical planning faces two major problems: 1) the correct identification the epileptogenic zone, which is frequently adjacent to but often not identical with the epileptogenic lesion, and its differentiation from functional brain tissue, which should be preserved during surgery; 2) the evaluation of the post-operative cognitive deficit, which depends on the residual functionality of the resected area. Beside medical and technological advances in the field of epilepsy surgery, reliable biomarkers guiding optimal resection of the epileptogenic zone are still lacking. Moreover, the neurophysiological evaluation of residual functionality in the epileptic brain is still poorly investigated.

In the past years I contributed to validate high frequency oscillations (HFO) in the intracranial EEG as an innovative biomarker for the delineation of the epileptogenic zone. While HFO are detected in the macro-scale EEG, known as local field potential, we combined routine clinical recordings with multi-unit neuronal activity and evaluated the relation between HFO and single unit activity in human tissue in vivo. In order to control for potential post-surgical cognitive deficit, we investigated the neurophysiological response during a set of cognitive paradigms. In this seminar I will present published results and ongoing analysis on intracranial EEG recording which are of interest to the clinical, neurophysiological an cognitive domain.

I will also present the project framework I plan to establish here in Moscow. We aim to perform clinical and cognitive assessment of pharmaco-resistant epilepsy patients designated for intracranial encephalography (iEEG) to guide surgical planning. The patients participating to our study will be first recorded in the magnetoencephalography (MEG) before receiving the stereo-iEEG implantation, then a similar set of recording will be performed after implantation in the intensive monitoring unit in the clinical institute. The output of our analysis will support the clinical evaluation and minimize post-operative cognitive deficit on single patient basis.